Journal article
Effectiveness of individualized lung recruitment strategies at birth: An experimental study in preterm lambs
DG Tingay, A Rajapaksa, E Zannin, PM Pereira-Fantini, RL Dellaca, EJ Perkins, CEE Zonneveld, A Adler, D Black, I Frerichs, A Lavizzari, M Sourial, B Grychtol, F Mosca, PG Davis
American Journal of Physiology Lung Cellular and Molecular Physiology | AMER PHYSIOLOGICAL SOC | Published : 2017
Abstract
Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung while aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume response and a dynamic tidal positive end-expiratory pressure (PEEP) (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment maneuver (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration, and lung injury in 127 ± 1 day preterm lambs. Forty-eight fetal-instrumented lambs exposed to antenatal steroids were ventilated for 60 min after application of the allo..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study is supported by a National Health and Medical Research Council Project Grant (Grant ID 1009287) and the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia). D. Tingay is supported by a National Health and Medical Research Council Clinical Career Development Fellowship (Grant ID 1053889). P. Davis is supported by a National Health and Medical Research Council Program Grant (Grant ID 606789). P. Davis is supported by a National Health and Medical Research Council Practitioner Fellowship (Grant ID 556600).